Droperidol

GENERIC NAME

Droperidol

TRADE NAME

Inapsine

DESCRIPTION

Droperidol (Inapsine) is a potent antiemetic and antipsychotic medication used for nausea, vomiting, and chemical restraint in agitated or violent patients.

HOW SUPPLIED

Intramuscular injection solution: 2.5 mg/1 mL

INDICATIONS

• Nausea and vomiting
• Sedation of acutely agitated and/or violent patients (chemical restraint)

CONTRAINDICATIONS

• Known hypersensitivity to Droperidol

MECHANISM OF ACTION

Droperidol is a butyrophenone neuroleptic (antipsychotic) that acts by antagonizing dopamine receptors in the central nervous system, similar to haloperidol.

SIDE EFFECTS

• Sinus tachycardia
• Hypotension
• Dystonic reactions
• Hallucinations
• Drowsiness
• Dizziness
• Chills
• Anxiety

AUTHORIZATION

EMT: Not authorized

EMT-I: Not authorized

Paramedic: Standing order

DOSAGE

• Adult:
  • Active vomiting: 1.25 mg IV; may repeat once after 10 minutes with Medical Control approval (max dose 2.5 mg).
  • Agitated/Psychosis (RASS Score +2): 5 mg IM.
  • Violent Patient (RASS Score ≥ +3): 10 mg IM; may repeat once after 20 minutes with Medical Control approval.
• Pediatric: Not given