Terbutaline
GENERIC NAME
Terbutaline
TRADE NAME
Brethine
DESCRIPTION
Terbutaline (Brethine) is a short-acting, selective beta-2 agonist that is used for the treatment and prevention of bronchospasm in both adult and pediatric patients. It is effective for managing bronchospasm due to asthma and is also used in cases of COPD-related bronchospasm in adults. It has a shorter duration of action compared to albuterol.
HOW SUPPLIED
Subcutaneous injection solution: 1 mg/mL
INDICATIONS
- Treatment of bronchospasm associated with COPD
- Treatment of bronchospasm due to asthma exacerbation
CONTRAINDICATIONS
- Known hypersensitivity to terbutaline or its components
MECHANISM OF ACTION
Terbutaline is a selective beta-2 adrenergic agonist with minimal effects on beta-1 receptors and no significant alpha receptor activity. It targets beta-2 receptors located on the bronchiolar smooth muscle, leading to bronchodilation. This action helps relax the bronchial smooth muscle and improves airflow in the lungs.
SIDE EFFECTS
- Injection site reaction
- Nausea
- Insomnia
- Anxiety
- Rash
- Headache
- Vomiting
- Dizziness
- Drowsiness
- Tremor
AUTHORIZATION
Paramedic: Standing order
DOSAGE
| Patient Type | Route | Dosage | Maximum Dosage |
|---|---|---|---|
| Adult | Subcutaneous (SQ) | 0.25 mg; may repeat once after 15 minutes if no significant improvement | 0.5 mg total within a 4-hour period |
| Pediatric | Subcutaneous (SQ) | 0.01 mg/kg (maximum single dose of 0.25 mg); may repeat once after 15 minutes if no significant improvement | 0.25 mg maximum per single dose |
Administration Notes:
- Administer subcutaneously in the upper arm, thigh, or abdomen.
- Monitor the patient for potential side effects, particularly tremors, dizziness, and increased heart rate.
- Do not exceed the maximum dosage limits to avoid increased risk of side effects.
- Reassess the patient after administration and consider additional interventions if symptoms persist.